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KMID : 0361120110250010038
Korean Journal of Transplantation
2011 Volume.25 No. 1 p.38 ~ p.42
Case of ABO-Incompatible Living Donor Kidney Transplantation without Blood Products in a Jehovah¡¯s Witness
Choi An-Sook

Yu Seong-Min
Lee Jin-Ho
Oh Joon-Seok
Kim Sung-Min
Shin Yong-Hun
Kim Joong-Kyung
Abstract
ABO-incompatible kidney transplantations have been performed successfully in Korea without splenectomy using plasmapheresis, anti-CD20 monoclonal antibody infusions and other immunosuppressants. However, there is no report of a case of ABO-incompatible kidney transplantation in a Jehovah¡¯s Witness. Hence, we report our experience of successful ABO-incompatible kidney transplantation without blood products in a Jehovah¡¯s Witness. The recipient was treated with six sessions of plasmapheresis and he received intravenous rituximab before transplantation. Immunosuppressive regimen consisted of tacrolimus, mycophenolate mofetil and steroid. The replacement fluid for plasmapheresis was 5% albumin solution instead of fresh frozen plasma. We measured the clotting factors before and after plasmapheresis and used cryoprecipitate to prevent bleeding.
KEYWORD
ABO-incompatible kidney transplantation, Clotting factors, Jehovah¡¯s Witness
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